Cladophorol A - CAS 146776-30-9

Cladophorol A is a cGAS inhibitor that obstructs its activity by binding to the conserved adenosine nucleotide binding site of cGAS. It effectively suppresses the overactivation of the cGAS-STING pathway at non-cytotoxic concentrations, with an IC50 of 370 nM. Cladophorol A holds potential for research into inflammatory diseases linked to the overactivation of the cGAS-STING pathway.

STING, cGAS

Immunology/Inflammation

146737

C13H8O6

260.2

O=C1OC2=CC(O)=C(O)C=C2C=3C=C(O)C(O)=CC13

-20°C

Ice Packs

Small Compound