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Claturafenib - CAS 2754408-94-9

Claturafenib - CAS 2754408-94-9

MF-0095023-01

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Product Details

  • Bioactivity

    Claturafenib (PF-07799933) is a brain-permeable, selective, all-mutant BRAF inhibitor with broad inhibitory effects on pERK levels in HT29 cells.Claturafenib has shown antitumor activity in preclinical studies in both BRAF V600- and non-V600-mutant cancers and can be used in combination with MEK inhibitors.

  • Target

    PERK, Raf

  • Related Pathways

    Apoptosis, MAPK

  • CAS Number

    2754305

  • Purity

    ≥99.99%

  • Molecular Formula

    C18H15Cl2F2N5O3S

  • Molecular Weight

    490.31

  • SMILES

    O=C1C2=C(N=CN1C)C=CC(NC=3C(F)=CC=C(NS(=O)(=O)N4CC(F)C4)C3Cl)=C2Cl

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound