Clesacostat tromethamine - CAS 2334472-62-5

Clesacostat (PF-05221304) is a potent and selective ACC inhibitor, with hACC1 IC50 of 13 nM and hACC2 IC50 of 9 nM. In animal models, PF-05221304 specifically inhibits hepatic DNL and demonstrates a significant safety margin for thrombocytopenia in non-human primate models.

2334405

C32H41N5O8

623.7

O=C(O)C=1C=CC(=CC1)C2=NC(OC)=CC(=C2)C(=O)N3CCC4(CC(=O)C5=C(C=NN5C(C)C)C4)CC3.OCC(N)(CO)CO

-20°C

Ice Packs

Small Compound