Clevudine - CAS 163252-36-6

Clevudine (Levovir) is a synthetic pyrimidine analogue with activity against hepatitis B virus (HBV) . Intracellularly, clevudine is phosphorylated to its active metabolites, clevudine monophosphate and triphosphate. The triphosphate metabolite competes with thymidine for incorporation into viral DNA, thereby causing DNA chain termination and inhibiting the function of HBV DNA polymerase (reverse transcriptase) . Clevudine has a long half-life and shows significant reduction of covalently closed circular DNA (cccDNA), therefore the patient is less likely to have a relapse after treatment is discontinued.

Virus Protease, DNA/RNA Synthesis, HBV

DNA Damage/DNA Repair, Cell Cycle/Checkpoint, Microbiology/Virology

163252-36-6

0.9998

C10H13FN2O5

260.22

Cc1cn([C@H]2O[C@@H](CO)[C@H](O)[C@H]2F)c(=O)[nH]c1=O

-20°C

Ice Packs

Small Compound