Clifutinib - CAS 1862226-99-0

Clifutinib (Compound 9e) is an orally active, selective inhibitor of FMS-like tyrosine kinase 3 (FLT3-ITD) with an IC50 of 15.1 nM. It inhibits FLT3-ITD kinase activity and blocks downstream signaling pathways, including RAS/MAPK, PI3K/AKT, and JAK/STAT5. Clifutinib induces apoptosis in FLT3-ITD mutated acute myeloid leukemia (AML) cells and is a potential candidate for research in relapsed/refractory FLT3-ITD positive AML.

PI3K, Akt, p38 MAPK, Apoptosis, FLT, Ras, STAT, JAK

Angiogenesis, Chromatin/Epigenetic, JAK/STAT signaling, PI3K/Akt/mTOR signaling, Tyrosine Kinase/Adaptors, MAPK, Cytoskeletal Signaling, GPCR/G Protein, Apoptosis, Stem Cells

1862127

C29H34N4O4

502.605

O=C(NC1=NOC(=C1)C(C)(C)C)NC2=CC=C(C#CC3=CC=C(OCCCN4CCOCC4)C=C3)C=C2

-20°C

Ice Packs

Small Compound