Clofarabine-5'-diphosphate - CAS 167620-89-5

Clofarabine-5'-diphosphate (Clofarabine-DP) is a metabolite resulting from the phosphorylation of Clofarabine by deoxycytidine kinase (dCK) . It can undergo further phosphorylation to become Clofarabine-5'-triphosphate, exhibiting cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.

DNA/RNA Synthesis

Cell Cycle/Checkpoint, DNA Damage/DNA Repair

167526

C10H13ClFN5O9P2

463.64

F[C@@H]1[C@H](N2C=3C(N=C2)=C(N)N=C(Cl)N3)O[C@H](COP(OP(=O)(O)O)(=O)O)[C@H]1O

-20°C

Ice Packs

Small Compound