(±) -Clopidogrel (hydrochloride) - CAS 130209-90-4

Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM) . Clopidogrel inhibits ADP-induced platelet aggregation ex vivo and functions as a prodrug whereupon biotransformation to its active metabolite via CYP2C19 in the liver enables its anti-aggregating activity. Marketed under the name Plavix , clopidogrel in combination with aspirin has been shown to be beneficial in the prevention of vascular ischemic events for patients without deficiencies in CYP2C19-related metabolism.

Others, P2Y Receptor

GPCR/G Protein, Neuroscience, Others

130115

C16H17Cl2NO2S

358.28

Cl.O=C(OC)C(C=1C=CC=CC1Cl)N2CC=3C=CSC3CC2

-20°C

Ice Packs

Small Compound