Clozapine dihydrochloride - CAS 2711603-38-0

Clozapine (HF 1854) dihydrochloride is utilized for researching psychiatric disorders. This compound exhibits high affinity for numerous neuroreceptors and acts as an effective antagonist of dopamine receptors, with a Ki value of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor, with Ki values of 9.5 nM and 4 nM, respectively. Additionally, Clozapine is a selective agonist of the muscarinic M4 receptor (EC50 = 11 nM) .

Dopamine Receptor, 5-HT Receptor, AChR, Adrenergic Receptor

GPCR/G Protein, Neuroscience

2711565

C18H21Cl3N4

399.75

ClC1=CC=C2NC3=C(C(N4CCN(CC4)C)=NC2=C1)C=CC=C3.Cl.Cl

-20°C

Ice Packs

Small Compound