Clozapine HCl - CAS 54241-01-9

Clozapine HCl is a tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.

Others, Dopamine Receptor, 5-HT Receptor, AChR, Adrenergic Receptor

Neuroscience, Others, GPCR/G Protein

54241-01-9

C18H20Cl2N4

363.29

Cl.CN1CCN(CC1)C1=NC2=C(NC3=C1C=CC=C3)C=CC(Cl)=C2

-20°C

Ice Packs

Small Compound