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Molfinity

CLP257 - CAS 1181081-71-9

CLP257 - CAS 1181081-71-9

MF-0032624-01

$38.41 USD
$38.41 USD
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Product Details

  • Bioactivity

    CLP257 is a selective K+-Cl− cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 alleviates hypersensitivity in rats with neuropathic painc and it also modulates plasmalemmal KCC2 protein turnover post-translationally. CLP257 restores impaired Cl− transport in neurons with diminished KCC2 activity.

  • Target

    Potassium Channel

  • Related Pathways

    Membrane transporter/Ion channel

  • CAS Number

    1181001

  • Purity

    0.995

  • Molecular Formula

    C14H14FN3O2S

  • Molecular Weight

    307.34

  • SMILES

    Oc1cc(F)ccc1\C=C1/SC(=NC1=O)N1CCCCN1

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound