ClpP modulator-1 - CAS 2363753-48-2

ClpPmodulator-1 (Compound BC8a) is a peptide mimic functioning as an allosteric ClpP modulator. At low concentrations, ClpPmodulator-1 acts as a ClpP activator, with EC50 values of 0.35 μM for Neisseria meningitides ClpP (NmClpP) and 0.58 μM for Escherichia coli ClpP (EcClpP) . At higher concentrations, it inhibits peptidase activity by competitively blocking substrate protein (LY-AMC) binding to the ClpPC site. ClpPmodulator-1 exhibits antibacterial properties and is applicable in bacterial infection research.

Protease

Proteases/Proteasome

2363703

C19H30BClN2O5

412.72

[C@H](C(N[C@@H](CC(C)C)B(O)O)=O)(NC(=O)C1=C(Cl)C=C(OC)C=C1)CC(C)C

-20°C

Ice Packs

Small Compound