Cmpd-A - CAS 1446399-26-3

Cmpd-A is a time-dependent CENP-E inhibitor with potent antitumor activity. Cmpd-A inhibits the ATPase activity of the CENP-E motor domain, acting as a time-dependent inhibitor with an ATP-competitive-like behavior. Cmpd-A causes chromosome misalignment on the metaphase plate, leading to prolonged mitotic arrest. Treatment with Cmpd-A induces antiproliferation in multiple cancer cell lines.

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1446370

C30H27F4N5O4S

629.63

C(N(CCN(C)C)C1C=2C(S(=O)(=O)C1)=C(C#N)C(C(F)(F)F)=CC2)(=O)C3=C(N4C(=N3)C=CC=C4OC)C5=CC(C)=C(F)C=C5

-20°C

Ice Packs

Small Compound