CNX-500 - CAS 1202758-21-1

CNX-500, a probe comprising a covalent Btk inhibitor chemically linked to biotin, exhibits significant inhibitory activity against Btk (IC50: 0.5 nM) and can form a covalent bond with Btk. Additionally, CNX-500 has low inhibitory effects on kinase EGFR and upstream Src-family kinases.

Others, BTK

Tyrosine Kinase/Adaptors, Angiogenesis, Others

1202736

C48H68N10O9S

961.18

[H][C@]12CS[C@@H](CCCCC(=O)NCCCOCCOCCOCCCNC(=O)CCCC(=O)NCCCOc3cccc(Nc4ncc(C)c(Nc5cccc(NC(=O)C=C)c5)n4)c3)[C@@]1([H])NC(=O)N2

-20°C

Ice Packs

Small Compound