Conoidin A - CAS 18080-67-6

Conoidin A is a cell-permeable inhibitor of the T. gondii enzyme peroxiredoxin II (TgPrxII) with nematicidal properties. It covalently binds to the peroxidatic Cys47 of TgPrxII, irreversibly inhibiting its hyperperoxidation activity with an IC50 of 23 μM. It also inhibits hyperoxidation of mammalian PrxI and PrxII (but not PrxIII) . Conoidin A has antioxidant, neuroprotective effects and can be used for research on ischaemic heart disease.

Parasite

Microbiology/Virology

18007

0.9877

C10H8Br2N2O2

347.99

[O-][n+]1c(CBr)c(CBr)[n+]([O-])c2ccccc12

-20°C

Ice Packs

Small Compound