Conophyllidine - CAS 152406-44-5

Conophyllidine is a bisindole alkaloid and functions as a selective inhibitor of M2 polarization. It inhibits histone acetylation by targeting the histone acetyltransferase domain of the P300/CBP proteins. The IC50 of Conophyllidine for IL-4-induced arginase inhibition is 0.31 μM. This compound effectively induces tumor-associated macrophages (TAMs) to shift from an anti-inflammatory to an inflammatory state, thereby enhancing the recruitment and function of cytotoxic CD8+ T cells in the tumor microenvironment. Conophyllidine is useful for studying tumor-associated macrophages.

Arginase, Histone Acetyltransferase

Immunology/Inflammation, Chromatin/Epigenetic

152357

C44H50N4O9

778.89

C(C)[C@@]12[C@]3([C@@]4(C(=C(C(OC)=O)C1)NC=5C4=CC(O)=C(OC)C5OC)CCN3[C@]6([C@@]([C@H]2O)(OC=7C6=CC8=C(C7)NC=9[C@@]8%10[C@@]%11([C@](CC)(CC9C(OC)=O)C=CCN%11CC%10)[H])[H])[H])[H]

-20°C

Ice Packs

Small Compound