α-Conotoxin BuIA - CAS 846539-62-6

α-Conotoxin BuIA is a paralytic peptide neurotoxin that acts as a competitive antagonist of nicotinic acetylcholine receptors (nAChR), with inhibitory concentration 50 (IC50) values of 0.258 nM for α6/α3β2, 1.54 nM for α6/α3β4, and 5.72 nM for α3β2. It serves to differentiate between nAChRs containing the β2- and β4-subunits and selectively inhibits αxβ2 nAChRs, exhibiting a potency hierarchy of α6>α3>α2>α4 [1].

AChR

Neuroscience

846471

C54H82N14O16S4

1311.57

O=C1[C@]2(N(C(=O)[C@]([C@@H](C)O)(NC(=O)[C@H](CO)NC(=O)[C@]3(NC(=O)[C@@H](NC(CN)=O)CSSC[C@](NC(=O)[C@]4(N1CCC4)[H])(C(=O)N[C@@H](C)C(=O)N[C@@H]([C@H](C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC5=CC=C(O)C=C5)C(=O)N[C@H](C(N)=O)CSSC3)[H])[H])[H])CCC2)[H]

-20°C

Ice Packs

Peptide