α-Conotoxin GID - CAS 547741-78-6

α-Conotoxin GID is a paralytic peptide neurotoxin that selectively antagonizes nAChR with IC50 values of 5 nM (α7), 3 nM (α3β2), and 150 nM (α4β2) . This small, disulfide-rich peptide has potential for chronic pain inhibition. The presence of a C-terminal carboxylate is crucial, as substitution with a C-terminal carboxamide results in loss of activity against α4β2 nAChR. Derived from species of the genus Conus [1] [2] [3].

AChR

Neuroscience

547657

C84H132N30O31S4

2186.39

O=C1[C@]2(N(C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@]3(NC(=O)[C@H](C)NC(=O)[C@]4(N(C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@](CSSC[C@@H](C(O)=O)NC(=O)[C@H]([C@@H](C)C)NC(=O)[C@H](CC5=CN=CN5)N1)(NC(=O)[C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]([C@H](CC)C)N)=O)CCCNC(=N)N)=O)CC(O)=O)=O)CC(C(O)=O)C(O)=O)=O)CSSC3)[H])CCC4)[H])[H])C[C@H](O)C2)[H]

-20°C

Ice Packs

Peptide