Copanlisib dihydrochloride - CAS 1402152-13-9

Copanlisib dihydrochloride (BAY 80-6946 dihydrochloride) is an ATP-competitive pan-class I PI3K inhibitor, with IC50 values of 0.5 nM for PI3Kα, 0.7 nM for PI3Kδ, 3.7 nM for PI3Kβ, and 6.4 nM for PI3Kγ. It exhibits superior antitumor activity and demonstrates more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR.

PI3K, Apoptosis, mTOR

Apoptosis, PI3K/Akt/mTOR signaling

1402130

0.9916

C23H30Cl2N8O4

553.44

Cl.Cl.COc1c(OCCCN2CCOCC2)ccc2C3=NCCN3C(NC(=O)c3cnc(N)nc3)=Nc12

-20°C

Ice Packs

Small Compound