Molfinity

Cot inhibitor-2 - CAS 915363-56-3

SKU:MF-0019104-01

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Size 1 mg 5 mg 1 mL - 10 mM (in DMSO) 10 mg 25 mg 50 mg 100 mg 200 mg

Product Details

Bioactivity
Cot inhibitor-2 is a cot (Tpl2/MAP3K8) inhibitor (IC50: 1.6 nM) with potency, selectivity and oral activity. cot inhibitor-2 inhibits LPS-stimulated TNF-α production in human whole blood with an IC50 of 0.3 μM.
Target
MAPK, TNF
Related Pathways
Apoptosis, MAPK
CAS Number
915304
Purity
0.9985
Molecular Formula
C26H25Cl2FN8
Molecular Weight
539.43
SMILES
CCN1CCC(CC1)n1cc(CNc2cc(Cl)c3ncc(C#N)c(Nc4ccc(F)c(Cl)c4)c3c2)nn1
Storage Temperature
-20°C
Shipping Conditions
Ice Packs
Category
Small Compound