Cotransin - CAS 863753-73-5

Cotransin, a Sec61 translocation inhibitor, selectively prevents the stable insertion of certain nascent chains into the Sec61 translocation channel, exhibiting signal-sequence discrimination. This compound also inhibits the expression of VCAM-1 and p-selectin proteins by blocking their co-translational translocation across endoplasmic reticulum (ER) membranes (IC 50 =0.5-5 μM) . Cotransin's role extends to potential applications in inflammation and immunity research [1] [2].

863753-73-5

C42H68N6O8

785.02

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