Covidcil-19 - CAS 1225177-95-6

Covidcil-19 binds to the revised attenuator hairpin structure of the SARS-CoV-2 frameshifting element (FSE) with high affinity (Kd = 11 nM) . It stabilizes the hairpin's folded state and reduces frameshifting efficiency in cells. Covidcil-19 inhibits viral propagation and reduces viral infectivity by > 3.5 orders of magnitude.

SARS-CoV, Others

Microbiology/Virology, Others

1225076

C16H14N4O2

294.31

N(C)C=1C2=C(N=C(NC3=CC(C(O)=O)=CC=C3)N1)C=CC=C2

-20°C

Ice Packs

Small Compound