COX-2/15-LOX-IN-5 - CAS 443790-30-5

COX-2/15-LOX-IN-5 (Compound 4f) functions as a dual inhibitor of COX-2 and 15-LOX, demonstrating both anti-inflammatory and antioxidant properties [1]. This compound effectively reduces NF-κB activation in RAW 264.7 macrophages that is induced by lipopolysaccharide.

Lipoxygenase, COX, NF-κB

NF-κB, Immunology/Inflammation, Metabolism, Neuroscience

443790-30-5

C25H21N3O3S

443.52

S(CC(NC1=CC=C(OC)C=C1)=O)C=2N(C(=O)C(=CC3=CC=CC=C3)N2)C4=CC=CC=C4

-20°C

Ice Packs

Small Compound