COX-2-IN-30 - CAS 1160498-08-7

COX-2-IN-30, a benzenesulfonamide derivative, is an orally active, dual inhibitor of cyclooxygenase-2 (COX-2; IC50 = 49 nM) and cyclooxygenase-1 (COX-1; IC50 = 10.4 μM), as well as 5-lipoxygenase (5-LOX; IC50 = 2.4 μM) . Additionally, it inhibits the transmembrane isoforms of human carbonic anhydrase IX and XII with nanomolar class Ki values. Demonstrating analgesic and anti-inflammatory properties, COX-2-IN-30 is devoid of acute gastric effects, avoiding ulcerogenic activity [1].

Lipoxygenase, Carbonic Anhydrase, COX

Neuroscience, Immunology/Inflammation, Metabolism

1160498-08-7

C17H16N6O3S

384.41

NC=1N(N=CC1C(NN=CC2=CC=CC=C2)=O)C3=CC=C(S(N)(=O)=O)C=C3

-20°C

Ice Packs

Small Compound