COX-2-IN-51 - CAS 3064260-49-4

COX-2-IN-51 (E25) is a potent COX-2 inhibitor with an IC50 of 70.7 nM. It significantly suppresses LPS-induced release of NO and PGE2, the expression of COX-2 and iNOS, and the activation of the NF-κB pathway. Displaying anti-inflammatory and analgesic effects in various mouse models through NF-κB pathway inhibition, COX-2-IN-51 has lower gastrointestinal side effects compared to Indomethacin.

COX, NF-κB

NF-κB, Neuroscience, Immunology/Inflammation

3064207

C23H18F4O3S

450.446

FC1=CC=C2OC(OCCC3=CSC=C3)(C(=CC2=C1)C=4C=CC(OC)=CC4)C(F)(F)F

-20°C

Ice Packs

Small Compound