COX-2-IN-55 - CAS 2649115-80-8

COX-2-IN-55 (compound 1) is an orally active Celecoxib analogue with broad-spectrum anticancer properties and relatively weak COX-2 inhibition. It specifically inhibits SERCA2, leading to increased caspase-3 cleavage and DR5 levels, which activates GRP78 and suppresses the progression of triple-negative breast cancer (TNBC) . Additionally, COX-2-IN-55 downregulates the angiogenesis markers VEGF-α and IL-8, thereby inhibiting microvessel formation.

Calcium Channel, VEGFR, Caspase

Metabolism, Tyrosine Kinase/Adaptors, Membrane transporter/Ion channel, Apoptosis, Angiogenesis, Proteases/Proteasome

2649027

C24H21F3N4O2S

486.51

O=S(=O)(NC=1C=CC=C(N)C1)C2=CC=C(C=C2)N3N=C(C=C3C=4C=C(C=CC4C)C)C(F)(F)F

-20°C

Ice Packs

Small Compound