CP 461 - CAS 227619-96-7

CP 461 (UNII-68OJX9I7DT), a specific PDE2A inhibitor, is a novel pro-apoptotic compound that inhibits cyclic GMP phosphodiesterase but not cyclooxygenase-1 or -2. CP 461 inhibits the growth of a variety of human tumor cell lines in vitro and selectively induces apoptosis in cancer cell lines, but not in normal cells.

PDE, Microtubule Associated, Apoptosis

Metabolism, Cytoskeletal Signaling, Apoptosis

227516

0.9982

C25H22ClFN2O

420.91

C(C(NCC1=CC=CC=C1)=O)C=2C=3C(/C(=C\C=4C=CN=CC4)/C2C)=CC=C(F)C3.Cl

-20°C

Ice Packs

Small Compound