CR-6086 - CAS 1417742-86-9

CR6086 is a novel, potent EP4 antagonist showing favourable immunomodulatory properties, striking DMARD effects in rodents, and anti-inflammatory activity targeted to immune-mediated inflammatory diseases and distinct from the general effects of cyclooxygenase inhibitors. CR6086 showed selectivity and high affinity for the human EP4 receptor (Ki = 16.6 nM) and functioned as a pure antagonist (half-maximal inhibitory concentration, 22 nM) on PGE2-stimulated cAMP production.

Others, MMP, Prostaglandin Receptor, PD-1/PD-L1, Interleukin

Immunology/Inflammation, GPCR/G Protein, Apoptosis, Cell Cycle/Checkpoint, Others, Proteases/Proteasome

1417647

C26H27F3N2O3

472.5

N(C(=O)C1N(CC2=CC=C(C(F)(F)F)C=C2)CCC3(C1)CC3)C4(CC4)C5=CC=C(C(O)=O)C=C5

-20°C

Ice Packs

Small Compound