Crebinostat - CAS 1092061-61-4

Crebinostat is a potent histone deacetylase (HDAC) inhibitor, targeting HDAC1, HDAC2, HDAC3, and HDAC6 with IC50s of 0.7 nM, 1.0 nM, 2.0 nM, and 9.3 nM, respectively. It increases the density of synapsin-1 punctae along dendrites in neurons in vitro, modulates chromatin-mediated neuroplasticity, and enhances memory in mice. Additionally, Crebinostat induces histone H3 and H4 acetylation and enhances the expression of Egr1, a cAMP-responsive element binding protein (CREB) target gene.

Histone Acetyltransferase, Epigenetic Reader Domain, HDAC

Chromatin/Epigenetic, DNA Damage/DNA Repair

1091996

0.9949

C20H23N3O3

353.41

C(=NNC(CCCCCC(NO)=O)=O)C1=CC=C(C=C1)C2=CC=CC=C2

-20°C

Ice Packs

Small Compound