Crenigacestat - CAS 1421438-81-4

Crenigacestat (LY3039478) is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most tumor cell lines tested. It effectively inhibits mutant Notch receptor activity and, in a xenograft tumor model, inhibits the expression of Notch-regulated genes and N1ICD cleavage in the tumor microenvironment.

Gamma-secretase

Proteases/Proteasome, Stem Cells, Neuroscience

1421353

0.9899

C22H23F3N4O4

464.44

C[C@H](NC(=O)CCC(F)(F)F)C(=O)N[C@H]1c2ccccc2-c2cccnc2N(CCO)C1=O

-20°C

Ice Packs

Small Compound