CSF1R-IN-22 - CAS 2760585-35-9

CSF1R-IN-22 (Compound C19), a potent orally administered CSF-1R selective inhibitor (IC50 <6 nM), significantly enhances CXCL9 secretion from M2 macrophages and promotes CD8+ T cell infiltration. Moreover, it amplifies the anti-tumor immune responses in conjunction with anti-PD-1 and triggers apoptosis in tumor cells. Additionally, CSF1R-IN-22 effectively reprograms M2-like TAMs (tumor-associated macrophages) to an M1 phenotype, modulates the tumor microenvironment (TME) by fostering the recruitment of CD8+ T cells, and diminishes the presence of immunosuppressive Tregs and MDSCs [1].

C-Fms, Apoptosis

Apoptosis, Tyrosine Kinase/Adaptors

2760585-35-9

C20H20N6O3

392.41

C(=C\1/C=2C(=CC(NC(NC=3C=C(C(C)(C)C)ON3)=O)=CC2)NC1=O)\C4=CN=CN4

-20°C

Ice Packs

Small Compound