CSF1R-IN-26 - CAS 3077238-23-1

CSF1R-IN-26 (Compound III-1) is an inhibitor of CSF-1R with an IC50 of 20.07 nM. It promotes the polarization of M2 macrophages to M1 macrophages, inducing apoptosis in MC-38 cancer cells. CSF1R-IN-26 inhibits the activation of the AKT/ERK/STAT3 signaling pathways, remodels the tumor immune microenvironment, and exhibits antitumor activity in mouse models. In SD rats, CSF1R-IN-26 demonstrates favorable pharmacokinetic properties, with a half-life of 1.86 hours and an oral bioavailability of 79.22%.

Apoptosis, Akt, ERK, STAT, c-Fms

Apoptosis, Stem Cells, Cytoskeletal Signaling, JAK/STAT signaling, MAPK, Tyrosine Kinase/Adaptors, PI3K/Akt/mTOR signaling

3077214

C20H22ClN5O3

415.87

O(C=1C=2C(NC1)=NC=C(Cl)C2)C3=C(C)N=C(NC(N[C@H]4[C@H](O)CCCC4)=O)C=C3

-20°C

Ice Packs

Small Compound