CSRM617 - CAS 787504-88-5

CSRM617 is a selective small molecule inhibitor of the transcription factor ONECUT2 (OC2, the main regulator of androgen receptor) . The Kd in SPR analysis is 7.43 uM, which can directly bind to the OC2-HOX domain. CSRM617 induces apoptosis by cleaving the presence of Caspase-3 and PARP. CSRM617 is well tolerated in a mouse model of prostate cancer.

Apoptosis, Androgen Receptor, Others

Endocrinology/Hormones, Apoptosis, Others

787411

C10H13N3O5

255.23

C(=NNC(C(CO)N)=O)C1=C(O)C(O)=C(O)C=C1

-20°C

Ice Packs

Small Compound