CSRM617 hydrochloride - CAS 1353749-74-2

CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor), with a Kd of 7.43 μM in SPR assays, directly binding to the OC2-HOX domain. CSRM617 hydrochloride induces apoptosis through the appearance of cleaved Caspase-3 and PARP and is well tolerated in the mouse model of prostate cancer [1].

Apoptosis, Androgen Receptor

Apoptosis, Endocrinology/Hormones

1353673

0.9959

C10H14ClN3O5

291.69

Cl.NC(CO)C(=O)N\N=C\c1ccc(O)c(O)c1O

-20°C

Ice Packs

Small Compound