CTSL/CAPN1-IN-2 - CAS 2410075-64-6

CTSL/CAPN1-IN-2 (Compound 14b) serves as an orally active inhibitor targeting both CTSL and CAPN1, manifesting IC50 values of 6.88 nM for CTSL and 347.6 nM for CAPN1 respectively. This compound not only displays anti-inflammatory attributes but also features favorable pharmacokinetic properties. Moreover, CTSL/CAPN1-IN-2 shows extensive antiviral effects against coronaviruses by inhibiting viral entry [1].

Cysteine Protease, SARS-CoV

Microbiology/Virology, Proteases/Proteasome

2410075-64-6

C34H40N4O6

600.7

C(N[C@@H](CC1CCCCC1)C(N[C@@H](C[C@H]2C(=O)NCCC2)C(C(NCC3=CC=CC=C3)=O)=O)=O)(=O)C4=CC=5C(O4)=CC=CC5

-20°C

Ice Packs

Small Compound