CU-32 - CAS 2400954-16-5

CU-32 is an inhibitor of cyclic GMP-AMP (cGAMP) synthase (cGAS; IC50= 0.45 μM) .1It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. It is also selective for cGAS over toll-like receptors (TLRs) at 50 μM. CU-32 decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells when used at concentrations of 10, 30, and 100 μM.

Others, cGAS

Immunology/Inflammation, Others

2400933

C11H10IN5O2

371.13

N(C=1N=C(C(OC)=O)N=C(N)N1)C2=CC=C(I)C=C2

-20°C

Ice Packs

Small Compound