CU-76 - CAS 2400954-58-5

CU-76 is an inhibitor of cyclic GMP-AMP synthase (cGAS; IC50= 0.24 μM) .1It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. CU-76 decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells when used at concentrations of 10, 30, and 100 μM.

CGAS, Others

Immunology/Inflammation, Others

2400891

C11H8F2IN5O2

407.11

N(C=1N=C(C(OC)=O)N=C(N)N1)C2=CC(F)=C(I)C(F)=C2

-20°C

Ice Packs

Small Compound