CU-T12-9 - CAS 1821387-73-8

CU-T12-9 is a potent TLR1/2 agonist (EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay) . It acts by activating the NFkB pathway, upregulating proinflammatory cytokines, and enhancing TLR1 and TLR2 dimerization.CU-T12-9 activates both the innate and the adaptive immune systems. CU-T12-9 selectively activates the TLR1/2 heterodimer, not TLR2/6. CU-T12-9 signals through NF-κB and invokes an elevation of the downstream effectors TNF-α, IL-10, and iNOS.

TLR

Immunology/Inflammation

1821306

0.9993

C17H13F3N4O2

362.31

CNc1ccc(cc1-n1cnc(c1)-c1ccc(cc1)C(F)(F)F)[N+]([O-])=O

-20°C

Ice Packs

Small Compound