Cucurbitacin B - CAS 6199-67-3

Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN. Cucurbitacin B is an effective inhibitor of HIF-1 and provide new perspectives into the mechanism of its anticancer activity. Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung Y cells.

Autophagy, HIF/HIF Prolyl-Hydroxylase, COX, STAT, PTEN, Integrin, Apoptosis, ROS Kinase, Endogenous Metabolite, HIF

Cytoskeletal Signaling, Apoptosis, Immunology/Inflammation, Tyrosine Kinase/Adaptors, Stem Cells, Autophagy, PI3K/Akt/mTOR signaling, Chromatin/Epigenetic, Metabolism, Angiogenesis, JAK/STAT signaling, Neuroscience

6199-67-3

0.9933

C32H46O8

558.7

CC(=O)OC(C)(C)C=CC(=O)C(C)(O)C1C(O)CC2(C)C3CC=C4C(CC(O)C(=O)C4(C)C)C3(C)C(=O)CC12C

-20°C

Ice Packs

Natural Product