CXCR3 Antagonist 6c - CAS 870998-13-3

CXCR3 antagonist 6c is an antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3) .1It inhibits calcium mobilization induced by chemokine (C-X-C motif) ligand 11 (CXCL11) in HEK293 cells expressing the human receptor (IC50= 0.06 μM) . It is selective for CXCR3 over a panel of 14 human G protein-coupled receptors at 10 μM. CXCR3 antagonist 6c inhibits CXCR3-mediated migration of isolated human T cells (IC50= ~100 nM) .

Others, CXCR

GPCR/G Protein, Others, Immunology/Inflammation, Autophagy

870982

C30H32Cl3N5O3

616.97

N(C(=O)C1=CC(Cl)=CC=C1)C2=C(C=CC(C(NCCC3=C(Cl)C=C(Cl)C=C3)=O)=C2)N4CCN(C(NCC)=O)CCC4

-20°C

Ice Packs

Small Compound