CXCR4 antagonist 6 - CAS 2304750-68-1

CXCR4 antagonist 6 (compound 46) is a highly potent inhibitor of CXCR4 with an IC50 value of 79 nM, effectively inhibiting the cytosolic calcium flux induced by CXCL12 with an IC50 of 0.25 nM. Additionally, it significantly mitigates cell migration mediated by the CXCL12/CXCR4 interaction and demonstrates remarkable efficacy in a mouse model of cancer metastasis [1].

Others, CXCR

Immunology/Inflammation, Others, Autophagy, GPCR/G Protein

2304681

1

C21H30N6

366.5

C(N1[C@@H](CCC1)C2=C(C)C=CC=N2)C=3C=C(N=C(C)N3)N4CCN(C)CC4

-20°C

Ice Packs

Small Compound