Cyano-myracrylamide - CAS 2801702-34-9

Cyano-myracrylamide is an inhibitor of zinc finger DHHC domain-containing palmitoyltransferase 20 (zDHHC20) with an IC50 value of 1.35 μM. It also inhibits the S-palmitoylation of EGFR and CD36. In HEK293T cells expressing recombinant E. coli GobX, recombinant human MyD88, or endogenous Ras, Cyano-myracrylamide inhibits the S-palmitoylation of E. coli E3 ligase GobX, MyD88, and Ras, which are substrates of zDHHC20, zDHHC9, and zDHHC6.

Acyltransferase

Metabolism

2801659

C19H34N2O

306.49

N#CCN(C(=O)C=C)CCCCCCCCCCCCCC

-20°C

Ice Packs

Small Compound