CYC-116 - CAS 693228-63-6

CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK2, Plk1 and SAPK2A. Phase 1.

VEGFR, FLT, Aurora Kinase, S6 Kinase, CDK

MAPK, Chromatin/Epigenetic, Tyrosine Kinase/Adaptors, PI3K/Akt/mTOR signaling, Angiogenesis, Cell Cycle/Checkpoint

693159

0.9759

C18H20N6OS

368.46

Cc1nc(N)sc1-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1

-20°C

Ice Packs

Small Compound