Cyclo (CLLFVY) - CAS 1446322-73-1

Cyclo (CLLFVY) is an inhibitor of hypoxia-inducible factor-1 (HIF-1), exhibiting half-maximal inhibitory concentrations (IC50) of 19 μM in U2OS cells and 16 μM in MCF-7 cells. It binds to the PAS-B domain of HIF-1α, inhibiting the dimerization and transcriptional activity of HIF-1. Moreover, cyclo (CLLFVY) downregulates the expression of hypoxia response genes (such as VEGF and CAIX), demonstrating antitumor effects against HIF-1-related cancers.

VEGFR, HIF/HIF Prolyl-Hydroxylase

Tyrosine Kinase/Adaptors, Angiogenesis, Chromatin/Epigenetic, Metabolism

1446322-73-1

C38H54N6O7S

738.94

C([C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@H](C(C)C)NC1=O)C3=CC=CC=C3

-20°C

Ice Packs

Peptide