Cyclo (L-Pro-L-Val) - CAS 2854-40-2

Cyclo (L-Pro-L-Val), a 2,5-diketopiperazine extracted from the fruits of Mycobacterium chiliolyticum AZ2 and Mycobacterium leprae, possesses anti-inflammatory activity and virulence activity against phytopathogenic microorganisms (e.g., R. fascians LMG 3605) and inhibits Gram-positive plant pathogens.Cyclo (L-Pro-L-Val) significantly inhibited IKKα phosphorylation and IκBα and NF-κB activation as well as iNOS and COX-2 activation in a concentration Cyclo (L-Pro-L-Val) significantly inhibited the phosphorylation of IKKα, IKKβ, IκBα, and NF-κB, as well as the activation of iNOS and COX-2 in a concentration-dependent manner, and is a potential therapeutic agent for the treatment of inflammation-related diseases.

COX, IκB/IKK, NOS, NF-κB, Antibacterial

Microbiology/Virology, Immunology/Inflammation, NF-κB, Neuroscience

2812

0.9818

C10H16N2O2

196.25

CC(C)[C@@H]1NC(=O)[C@@H]2CCCN2C1=O

-20°C

Ice Packs

Peptide