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Cyclosporin A - CAS 59865-13-3
Cyclosporin A - CAS 59865-13-3
SKU:MF-0003997-01
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Product Details
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Bioactivity
Cyclosporin A is a natural product and an active fungal metabolite, classified as a cyclic polypeptide immunosuppressant. It binds to cyclophilin and inhibits the activity of calcineurin (IC50 = 7 nM) as well as CD11a/CD18 adhesion molecules. It is commonly used to induce uremia models.
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Target
Phosphatase, Complement System, Antibiotic
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Related Pathways
Microbiology/Virology, Metabolism, Immunology/Inflammation
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CAS Number
59849
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Purity
0.9999
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Molecular Formula
C62H111N11O12
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Molecular Weight
1202.61
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SMILES
[C@H]([C@@H](C/C=C/C)C)(O)[C@@]1(N(C)C(=O)[C@H]([C@@H](C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H]([C@H](C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@H](CC)NC1=O)[H]
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Storage Temperature
-20°C
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Shipping Conditions
Ice Packs
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Category
Natural Product