Cylindrospermopsin - CAS 143545-90-8

Cylindrospermopsin, a tricyclic uracil derivative, is a cyanobacterial toxin that was first discovered in an algal bloom contaminating a local drinking supply on Palm Island in Queensland, Australia after an outbreak of a mysterious disease. Cylindrospermopsin targets protein and glutathione synthesis in hepatocytes (IC50s = 1.3 and 2.4 &#181M, respectively), leading to cell death. [1] It has been shown to inhibit the activity of the uridine monophosphate synthase complex with a Ki value of 10 &#181M.[2] Cylindrospermopsin is genotoxic, inducing DNA damage as evidenced by double strand breaks and reducing cell viability in HepG2 cells at 0.1-0.5 &#181g/ml.[3]

DNA/RNA Synthesis, Others

Cell Cycle/Checkpoint, Others, DNA Damage/DNA Repair

143447

C15H21N5O7S

415.42

C[C@@H]1[C@@]2(N3[C@@](C[C@]([C@@H](O)C4=CC(=O)NC(=O)N4)(N=C3NC2)[H])(C[C@@H]1OS(=O)(=O)O)[H])[H]

-20°C

Ice Packs

Natural Product