CYP1B1-IN-9 - CAS 3077254-39-5

CYP1B1-IN-9 is a highly selective and competitive CYP1B1 inhibitor, with IC50 values of 1.48 nM for CYP1B1, and greater than 100 μM and 80 μM for CYP1A1 and CYP1A2, respectively. This compound effectively inhibits the migration and invasion of A549/T cells, offers the potential to resensitize paclitaxel-resistant cells, and exhibits good metabolic stability and safety, as well as favorable pharmacokinetic properties. CYP1B1-IN-9 is applicable in research on tumor resistance.

Cytochromes P450

Metabolism

3077210

C16H9Cl3N2OS

383.68

O=C(NC=1C=C(Cl)C=C(Cl)C1)C2=NC(=CS2)C=3C=CC=C(Cl)C3

-20°C

Ice Packs

Small Compound