CYP2E1-IN-1 - CAS 38205-55-9

CYP2E1-IN-1 (Compound 10) is an orally active inhibitor of cytochrome P450 2E1 (CYP2E1) with a dissociation constant (Kd) of 7.02 μM, an IC50 of 1.64 μM, and a Ki of 0.897 μM. It alleviates pancreatic damage by activating the Nrf2/HO-1 signaling pathway and inhibiting ROS production. CYP2E1-IN-1 demonstrates significant anti-inflammatory and antioxidant properties, effectively reducing inflammation and oxidative stress in severe acute pancreatitis (SAP) . It is suitable for the study of SAP and other inflammation-related conditions.

ROS, Nrf2, Cytochromes P450, Reactive Oxygen Species

Metabolism, Immunology/Inflammation, NF-κB

38141

C6H7NOS

141.19

O=C(C=1SC=NC1C)C

-20°C

Ice Packs

Small Compound