Cytarabine 5′-monophosphate - CAS 7075-11-8

Cytarabine 5′-monophosphate (ara-CMP), an active metabolite of the nucleoside analog cytarabine formed by deoxycytidine kinase, is incorporated into DNA by DNA polymerase α, significantly slowing DNA synthesis. It inhibits nuclear and mitochondrial DNA replication in S. cerevisiae at 15 mM and improves survival in an L1210 murine leukemia model at 3.5-75.1 mg/kg.

Others, Drug Metabolite, DNA/RNA Synthesis

Others, DNA Damage/DNA Repair, Cell Cycle/Checkpoint, Metabolism

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C9H14N3O8P

323.198

Nc1ccn([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]2O)c(=O)n1

-20°C

Ice Packs

Small Compound