Cytochalasin D - CAS 22144-77-0

Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertilization processes such as sperm penetration or sperm head decondensation. Cytochalasin D inhibits CT26 tumor growth potentially through inhibition of cell proliferation, induction of cell apoptosis and suppression of tumor angiogenesis; it stimulates the expression of TF in B16 melanoma cells, activating both coagulation-dependent and -independent pathways via binding to FVIIa, eventually promoting lung metastasis. Cytochalasin D is also an inhibitor of microfilament-dependent phagocytosis, it (0.5 or 1.0 micrograms/ml) can inhibit intracellular multiplication of L. pneumophila in U937 monocytes. Cytochalasin D inhibits smooth muscle contraction by directly inhibiting contractile apparatus.

PI3K, Calcium Channel, Factor VIIa, p38 MAPK, Akt, ATPase, YAP, Arp2/3 Complex, Antibiotic

Microbiology/Virology, PI3K/Akt/mTOR signaling, MAPK, Stem Cells, Cytoskeletal Signaling, Membrane transporter/Ion channel, Metabolism

22067

0.99586

C30H37NO6

507.62

[H][C@]12[C@H](Cc3ccccc3)NC(=O)[C@@]11[C@H](OC(C)=O)\C=C\[C@@](C)(O)C(=O)[C@@H](C)C\C=C\[C@@]1([H])[C@H](O)C(=C)[C@H]2C

-20°C

Ice Packs

Natural Product